diff --git a/MdeModulePkg/Bus/Usb/UsbMouseDxe/UsbMouse.c b/MdeModulePkg/Bus/Usb/UsbMouseDxe/UsbMouse.c
index 677815a8ad..143ff15eb0 100644
--- a/MdeModulePkg/Bus/Usb/UsbMouseDxe/UsbMouse.c
+++ b/MdeModulePkg/Bus/Usb/UsbMouseDxe/UsbMouse.c
@@ -203,7 +203,7 @@ USBMouseDriverBindingStart (
   EndpointNumber = UsbMouseDevice->InterfaceDescriptor.NumEndpoints;
 
   //
-  // Traverse endpoints to find interrupt endpoint
+  // Traverse endpoints to find interrupt endpoint IN
   //
   Found = FALSE;
   for (Index = 0; Index < EndpointNumber; Index++) {
@@ -213,7 +213,8 @@ USBMouseDriverBindingStart (
              &EndpointDescriptor
              );
 
-    if ((EndpointDescriptor.Attributes & (BIT0 | BIT1)) == USB_ENDPOINT_INTERRUPT) {
+    if (((EndpointDescriptor.Attributes & (BIT0 | BIT1)) == USB_ENDPOINT_INTERRUPT) &&
+        ((EndpointDescriptor.EndpointAddress & USB_ENDPOINT_DIR_IN) != 0)) {
       //
       // We only care interrupt endpoint here
       //