diff --git a/MdeModulePkg/Core/Dxe/Mem/HeapGuard.h b/MdeModulePkg/Core/Dxe/Mem/HeapGuard.h
index 24b4206c0e..578e857465 100644
--- a/MdeModulePkg/Core/Dxe/Mem/HeapGuard.h
+++ b/MdeModulePkg/Core/Dxe/Mem/HeapGuard.h
@@ -469,4 +469,18 @@ PromoteGuardedFreePages (
 
 extern BOOLEAN  mOnGuarding;
 
+//
+// The heap guard system does not support non-EFI_PAGE_SIZE alignments.
+// Architectures that require larger RUNTIME_PAGE_ALLOCATION_GRANULARITY
+// cannot have EfiRuntimeServicesCode, EfiRuntimeServicesData, EfiReservedMemoryType,
+// and EfiACPIMemoryNVS guarded. OSes do not map guard pages anyway, so this is a
+// minimal loss. Not guarding prevents alignment mismatches
+//
+STATIC_ASSERT (
+  RUNTIME_PAGE_ALLOCATION_GRANULARITY == EFI_PAGE_SIZE ||
+  (((FixedPcdGet64 (PcdHeapGuardPageType) & 0x461) == 0) &&
+   ((FixedPcdGet64 (PcdHeapGuardPoolType) & 0x461) == 0)),
+  "Unsupported Heap Guard configuration on system with greater than EFI_PAGE_SIZE RUNTIME_PAGE_ALLOCATION_GRANULARITY"
+  );
+
 #endif
diff --git a/MdeModulePkg/Core/Dxe/Mem/Page.c b/MdeModulePkg/Core/Dxe/Mem/Page.c
index cd201d36a3..26584648c2 100644
--- a/MdeModulePkg/Core/Dxe/Mem/Page.c
+++ b/MdeModulePkg/Core/Dxe/Mem/Page.c
@@ -1411,6 +1411,17 @@ CoreInternalAllocatePages (
     Alignment = RUNTIME_PAGE_ALLOCATION_GRANULARITY;
   }
 
+  //
+  // The heap guard system does not support non-EFI_PAGE_SIZE alignments.
+  // Architectures that require larger RUNTIME_PAGE_ALLOCATION_GRANULARITY
+  // will have the runtime memory regions unguarded. OSes do not
+  // map guard pages anyway, so this is a minimal loss. Not guarding prevents
+  // alignment mismatches
+  //
+  if (Alignment != EFI_PAGE_SIZE) {
+    NeedGuard = FALSE;
+  }
+
   if (Type == AllocateAddress) {
     if ((*Memory & (Alignment - 1)) != 0) {
       return EFI_NOT_FOUND;
diff --git a/MdeModulePkg/Core/Dxe/Mem/Pool.c b/MdeModulePkg/Core/Dxe/Mem/Pool.c
index ccfce8c5f9..72293e6dfe 100644
--- a/MdeModulePkg/Core/Dxe/Mem/Pool.c
+++ b/MdeModulePkg/Core/Dxe/Mem/Pool.c
@@ -380,6 +380,17 @@ CoreAllocatePoolI (
     Granularity = DEFAULT_PAGE_ALLOCATION_GRANULARITY;
   }
 
+  //
+  // The heap guard system does not support non-EFI_PAGE_SIZE alignments.
+  // Architectures that require larger RUNTIME_PAGE_ALLOCATION_GRANULARITY
+  // will have the runtime memory regions unguarded. OSes do not
+  // map guard pages anyway, so this is a minimal loss. Not guarding prevents
+  // alignment mismatches
+  //
+  if (Granularity != EFI_PAGE_SIZE) {
+    NeedGuard = FALSE;
+  }
+
   //
   // Adjust the size by the pool header & tail overhead
   //
diff --git a/MdeModulePkg/MdeModulePkg.dec b/MdeModulePkg/MdeModulePkg.dec
index a2cd83345f..a82dedc070 100644
--- a/MdeModulePkg/MdeModulePkg.dec
+++ b/MdeModulePkg/MdeModulePkg.dec
@@ -1027,6 +1027,11 @@
   # free pages for all of them. The page allocation for the type related to
   # cleared bits keeps the same as ususal.
   #
+  # The heap guard system only supports guarding EfiRuntimeServicesCode, EfiRuntimeServicesData,
+  # EfiReservedMemoryType, and EfiACPIMemoryNVS memory types for systems that have
+  # RUNTIME_PAGE_ALLOCATION_GRANULARITY == EFI_PAGE_SIZE. This is to preserve alignment requirements
+  # without extending the page guard size to very large granularities.
+  #
   # This PCD is only valid if BIT0 and/or BIT2 are set in PcdHeapGuardPropertyMask.
   #
   # Below is bit mask for this PCD: (Order is same as UEFI spec)<BR>
@@ -1058,6 +1063,11 @@
   # if there's enough free memory for all of them. The pool allocation for the
   # type related to cleared bits keeps the same as ususal.
   #
+  # The heap guard system only supports guarding EfiRuntimeServicesCode, EfiRuntimeServicesData,
+  # EfiReservedMemoryType, and EfiACPIMemoryNVS memory types for systems that have
+  # RUNTIME_PAGE_ALLOCATION_GRANULARITY == EFI_PAGE_SIZE. This is to preserve alignment requirements
+  # without extending the page guard size to very large granularities.
+  #
   # This PCD is only valid if BIT1 and/or BIT3 are set in PcdHeapGuardPropertyMask.
   #
   # Below is bit mask for this PCD: (Order is same as UEFI spec)<BR>